28. Oct 2022
Recently, a Korea-Spain joint research team recreated bioplastic from wasted by-products from gas fermentation from steel mills.
Through joint research with Spain’s Center for Research in Agricultural Genomics (CRAG – Barcelona), a research team led by Gyoo Yeol Jung, Dae-yeol Ye, Jo Hyun Moon, and Myung Hyun Noh in the Department of Chemical Engineering at POSTECH (Pohang, South Korea) has developed a technology to generate artificial enzymes from E. coli. The joint research then succeeded in mass-producing itaconic acid, a source material for bioplastic, from acetic acid in E. coli.
Recognized for its significance, this study was recently published in the Editor’s Highlights section of the international academic journal Nature Communications.
Itaconic acid produced by fungi with membrane-enclosed organelles is used as a raw material for various plastics, as well as cosmetics and antibacterial agents. Although its global market value is estimated high at around 130 billion KRW (USD 91 million) this year, its production and utilization have been limited due to the complex production process and high cost of production.
For this reason, studies are being actively conducted to produce itaconic acid with industrial microorganisms such as E. coli. Although E. coli can be produced using inexpensive raw materials and is easy to culture, additional raw materials or processes were required to produce itaconic acid since it lacks membrane-enclosed organelles.
Using biosynthesis, the joint research team developed an artificial enzyme to pave the way for E. coli to directly produce itaconic acid without membrane-enclosed organelles. The research results showed that the newly developed enzyme can be used in E. coli to produce itaconic acid. With this technology, it is now possible to build a microbial cell factory that can easily produce itaconic acid from cheap and various raw materials.
This research result is evaluated as a key original technology for producing itaconic acid from byproduct of gas fermentation products from steel mills, seaweed, as well as agricultural and fishery byproducts such as lignocellulosic biomass*1. By replacing the raw material from petrochemicals with biosynthesized itaconic acid, the new technology is anticipated to contribute to a carbon-neutral society and significantly expand the itaconic acid market.
This study was supported by the C1 Gas Refinery R&D Program, the Mid-career Researcher Program, and the Basic Science Program of the National Research Foundation of Korea. AT