Russian researchers create innovative nanofibrous biopolymer material

14.08.2017

Researchers at the G.V. Plekhanov Russian University of Economics, together with their colleagues from N.M. Emanuel Institute of Biochemical Physics of RAS and N.N. Semenov Institute of Chemical Physics of RAS, have developed a new type of nanofibrous biopolymer materials.

mThese materials have unique properties and can be used to manufacture the shells and capsules of medicinal products, bactericidal dressings, filtering and protective materials. The material is also suitable for use in bioresorbable implants (it will be replaced with bone tissue over time).

The researchers used an electroforming process to synthesize ultrafine fibres based on poly-3-hydroxybutyrate, a process in which micro- and nanofibres of any length are produced from polymer melts in an electrodynamic field under the impact of high voltage.

The new polymers contain a small concentration of iron (III) complex and tetraphenylporphyrin, a heterocyclic compound that is an analogue of natural porphyrins. Bactericidal properties were achieved through the introduction of metal complexes of porphyrins, while the addition of the iron (III) complex increased the electroconductivity of the biopolymer melt used to form the ultrathin fibres, which increased the productivity of the manufacturing process for this material.

The researchers have already created anti-wound antimicrobial dressings, as well as Achilles tendon implants, based on the new material containing haemostatic elements. The bactericidal additive with the iron complex is similar to haemoglobin - the haeme-containing protein molecule in red blood cells that carries oxygen from the lungs to the body's tissues. Haeme is an iron-containing compound.
As a result, the material not only disinfects wounds, it also promotes rapid blood clotting.

“The technology has great potential, the ultrathin fibers have various diameters and properties that allow them to be used in the production of products for various purposes, including scaffolds for growing living cells, as a controlled release matrix for medicines, , bactericidal wound dressings, bioresorbable implants, protective and filtering systems, " said a spokesperson.

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The technology has been patented.

http://gmpnews.ru/2017/07/v-rossii-sozdan-novyj-vid-nanovoloknistyx-biopolimernyx-materialov/


Images:

-Nanofibres 

-A sample of nanofibrous polymeric material and Achilles tendon implant